pentobarbital will reduce the level or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Pitolisant exposure is lowered by fifty% if coadministered with sturdy CYP3A4 inducers.pentobarbital will lessen the extent or impact of abiraterone by influencing hepatic/intestinal enzyme CYP3A4 m